These extremely strange diseases are bound to evoke everything from pity and disgust to sheer shock!
Werewolf Syndrome
Imagine meeting a person with dark, hairy patches, akin to that of a wild animal's, on their face! Well, apparently it wouldn't be entirely politically incorrect to think of them as werewolves because that's exactly what this disease is called--werewolf syndrome! Of course, it comes minus the awesomeness of the sharp teeth and the power of the moon--but the appearance is all those inflicted by this disease get.
This too is a fairly rare disease, but there is a family in Mexico in which all the men had this genetic fault leading to this strange appearance. Incidentally, two of the brothers from this family were even offered a role in the x-files, but they turned it down.
-Picture courtesy telegraph.co.uk-